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Spontaneous liver tumors and Benzo[a]pyrene-induced lymphomas in XPA-deficient mice

1 May 1997

Abstract excerpt

Defects in the xeroderma pigmentosum complementation group A-correcting (XPA) gene, which encodes a component of the nucleotide excision repair (NER) pathway, are associated with the cancer-prone human disease xeroderma pigmentosum. We previously generated mice lacking the XPA gene, which develop normally but are highly sensitive to ultraviolet-B and 7,12-dimethylbenz[a] anthracene-induced skin tumors. Here we...

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PMID: 9180928
DOI: 10.1002/(sici)1098-2744(199705)19:1<46::aid-mc7>3.0.co;2-l

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