Article
Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy.
Circulation research - 3 Sept 2004
Schroen Blanche, Heymans Stephane, Sharma Umesh, Blankesteijn W Matthijs, Pokharel Saraswati, Cleutjens Jack P M, Porter J Gordon, Evelo Chris T A, Duisters Rudy, van Leeuwen Rick E W, Janssen Ben J A, Debets Jacques J M, Smits Jos F M, Daemen Mat J A P, Crijns Harry J G M, Bornstein Paul, Pinto Yigal M
Abstract excerpt
Cardiac hypertrophy can lead to heart failure (HF), but it is unpredictable which hypertrophied myocardium will progress to HF. We surmised that apart from hypertrophy-related genes, failure-related genes are expressed before the onset of failure, permitting molecular prediction of HF. Hearts from hypertensive homozygous renin-overexpressing (Ren-2) rats that had progressed to early HF were compared by microarray...
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