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Article

Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2011

Xia Ying, Dobaczewski Marcin, Gonzalez-Quesada Carlos, Chen Wei, Biernacka Anna, Li Na, Lee Dong-Wook, Frangogiannis Nikolaos G

Abstract excerpt

The matricellular protein thrombospondin (TSP) 1 is induced after tissue injury and may regulate reparative responses by activating transforming growth factor-β, by suppressing angiogenesis and by modulating inflammation and matrix metabolism. We hypothesized that endogenous TSP-1 may be involved in the pathogenesis of cardiac remodeling in the pressure-overloaded heart. Myocardial TSP-1 expression was increased...

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Identifiers

PMID: 21947471
DOI: 10.1161/HYPERTENSIONAHA.111.175323
PMCID: PMC3199343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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