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Article

Thrombospondin-4 knockout in hypertension protects small-artery endothelial function but induces aortic aneurysms.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2016

Palao Teresa, Rippe Catarina, van Veen Henk, VanBavel Ed, Swärd Karl, Bakker Erik N T P

Abstract excerpt

Thrombospondin-4 (TSP-4) is a multidomain calcium-binding protein that has both intracellular and extracellular functions. As an extracellular matrix protein, it is involved in remodeling processes. Previous work showed that, in the cardiovascular system, TSP-4 expression is induced in the heart in response to experimental pressure overload and infarction injury. Intracellularly, it mediates the endoplasmic...

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Identifiers

PMID: 26968543
DOI: 10.1152/ajpheart.00046.2016

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ANG

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