Article
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.
Circulation - 18 Mar 2008
Kontaridis Maria I, Yang Wentian, Bence Kendra K, Cullen Darragh, Wang Bo, Bodyak Natalya, Ke Qingen, Hinek Aleksander, Kang Peter M, Liao Ronglih, Neel Benjamin G
Abstract excerpt
BACKGROUND: Heart failure is the leading cause of death in the United States. By delineating the pathways that regulate cardiomyocyte function, we can better understand the pathogenesis of cardiac disease. Many cardiomyocyte signaling pathways activate protein tyrosine kinases. However, the role...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.