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Article

Improved generation of germline-competent embryonic stem cell lines from inbred mouse strains.

Stem cells (Dayton, Ohio) - 1 Jan 2003

Schoonjans Luc, Kreemers Veerle, Danloy Sophie, Moreadith Randall W, Laroche Yves, Collen Désiré

Abstract excerpt

Genetically altered mice may exhibit highly variable phenotypes due to the variation in genetic background, which can only be circumvented by generation of inbred, isogenic gene-targeted and control mice. Here we report that an embryonic stem (ES) cell culture medium conditioned by a rabbit fibroblast cell line transduced with genomic rabbit leukemia inhibitory factor allows efficient derivation and maintenance...

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PMID: 12529555
DOI: 10.1634/stemcells.21-1-90

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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