A new coat color mouse line for testing germline transmission of embryonic stem cells while retaining an inbred genetic background.

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Article

A new coat color mouse line for testing germline transmission of embryonic stem cells while retaining an inbred genetic background.

Journal of the American Association for Laboratory Animal Science : JAALAS - 1 May 2007

Barbaric Ivana, Stewart Michelle, Wells Sara, Dear T Neil

Abstract excerpt

Most gene-targeted mice are produced on a mixed genetic background of C57BL/6 and substrains of 129/Sv. Mating chimeric mice containing 129/Sv-derived embryonic stem cells that are wild type at the agouti locus (A) in a nonagouti (a) donor genetic background with inbred C57BL/6 mice that are homozygous for the nonagouti allele allows the use of coat color to detect germline transmission. Agouti pups from such a...

Topics

Agouti Signaling Protein
Alleles
Animals
Chimera
Color
Embryonic Stem Cells
Genetic Markers
Germ-Line Mutation
Hair
Inbreeding
Intercellular Signaling Peptides and Proteins
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Models, Animal
Mutation

Source

Open in PubMed

Identifiers

PMID: 17487951

Provenance

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