Article

Genetic mapping of species differences via “ <i>in vitro</i> crosses” in mouse embryonic stem cells

2017-06-10

Abstract excerpt

Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. However, hybrid crosses between species in mammals often suffer from hybrid sterility, greatly complicating genetic dissection of trait variation. Here we describe a simple, robust and transgene-free technique to make “ in vitro crosses” in hybrid mouse embryonic stem cells by inducing random mitotic crossov...

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Literature Corpus work: 02faff19-5db8-5cbe-885e-05e59cc0b060
DOI: 10.1101/148486

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