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Article

Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling.

Journal of the American Heart Association - 18 Feb 2025

Suominen Anni, Suni Aino, Ruohonen Saku, Szabó Zoltán, Pohjolainen Lotta, Cai Minying, Savontaus Eriika, Talman Virpi, Kerkelä Risto, Rinne Petteri

Abstract excerpt

BACKGROUND: The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses. Recently, MC1R was also found in the heart, but its functional role has remained unknown. We aimed to investigate whether MC1R is involved in the regulation of pathological or physiological cardiac remodeling. METHODS AND RESULTS: Recessive yellow...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypertrophy, Left Ventricular

Share to Mice, Knockout

Share to Myocytes, Cardiac

Share to Receptor, Melanocortin, Type 1

Share to Ventricular Function, Left

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Source

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Identifiers

PMID: 39921516
DOI: 10.1161/JAHA.124.037961
PMCID: PMC12074753

Genes

MC1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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