Article
The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning.
Peptides - 1 Jan 2010
Catania Anna, Lonati Caterina, Sordi Andrea, Leonardi Patrizia, Carlin Andrea, Gatti Stefano
Abstract excerpt
alpha-Melanocyte-stimulating hormone (alpha-MSH) is a pro-opiomelanocortin (POMC)-derived peptide that exerts multiple protective effects on host cells. Previous investigations showed that treatment with alpha-MSH or synthetic melanocortin agonists reduces heart damage in reperfusion injury and transplantation. The aim of this preclinical research was to determine whether melanocortin treatment induces...
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