Article
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2008
Leoni Giovanna, Patel Hetal B, Sampaio André L F, Gavins Felicity N E, Murray Joanne F, Grieco Paolo, Getting Stephen J, Perretti Mauro
Abstract excerpt
The existence of anti-inflammatory circuits centered on melanocortin receptors (MCRs) has been supported by the inhibitory properties displayed by melanocortin peptides in models of inflammation and tissue injury. Here we addressed the pathophysiological effect that one MCR, MCR type 3 (MC3R), might have on vascular inflammation. After occlusion (35 min) and reopening of the superior mesenteric artery, MC3R-null...
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