Article
IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture.
Clinical science (London, England : 1979) - 12 Jun 2020
Ghali Rana, Habeichi Nada J, Kaplan Abdullah, Tannous Cynthia, Abidi Emna, Bekdash Amira, Farhat Rima, Itani Hana, Jurjus Abdo, Booz George W, Mallat Ziad, Zouein Fouad A
Abstract excerpt
Myocardial infarction (MI) is the leading cause of mortality worldwide. Interleukin (IL)-33 (IL-33) is a cytokine present in most cardiac cells and is secreted on necrosis where it acts as a functional ligand for the ST2 receptor. Although IL-33/ST2 axis is protective against various forms of cardiovascular diseases, some studies suggest potential detrimental roles for IL-33 signaling. The aim of the present...
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