Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5.

doi:10.1152/ajpheart.00152.2004

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Article

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2004

Folco Eduardo J, Liu Gong-Xin, Koren Gideon

Abstract excerpt

The targeting of ion channels to particular membrane microdomains and their organization in macromolecular complexes allow excitable cells to respond efficiently to extracellular signals. In this study, we describe the formation of a complex that contains two scaffolding proteins: caveolin-3 (Cav-3) and a membrane-associated guanylate kinase (MAGUK), SAP97. Complex formation involves the association of Cav-3 with...

Topics

Animals
Binding Sites
CHO Cells
COS Cells
Caveolin 3
Caveolins
Chlorocebus aethiops
Cricetinae
Glycosylation
Kv1.5 Potassium Channel
Mutation
Nerve Tissue Proteins
Potassium Channels, Voltage-Gated
Protein Structure, Tertiary

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Identifiers

PMID: 15277200
DOI: 10.1152/ajpheart.00152.2004

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