Article

Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells

2025-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated autoimmunity and microglia-mediated neuroinflammation. Kv1.3 channels, via protein-protein interactions, are localized with key immune proteins and pathways, enabling function...

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Literature Corpus work: 8540a643-648c-5aff-9bdf-b20fd8c14fb0
DOI: 10.1101/2025.01.16.633279

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