Article
Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
Cell - 7 Apr 2016
Zhang Yalan, Zhang Xiao-Feng, Fleming Matthew R, Amiri Anahita, El-Hassar Lynda, Surguchev Alexei A, Hyland Callen, Jenkins David P, Desai Rooma, Brown Maile R, Gazula Valeswara-Rao, Waters Michael F, Large Charles H, Horvath Tamas L, Navaratnam Dhasakumar, Vaccarino Flora M, Forscher Paul, Kaczmarek Leonard K
Abstract excerpt
Mutations in the Kv3.3 potassium channel (KCNC3) cause cerebellar neurodegeneration and impair auditory processing. The cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3. We found that Kv3.3 recruits Arp2/3 to the plasma membrane, resulting in formation of a relatively stable cortical actin filament network resistant to cytochalasin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.