Article
Mechanisms of MAGUK-mediated cellular junctional complex organization.
Current opinion in structural biology - 1 Feb 2018
Ye Fei, Zeng Menglong, Zhang Mingjie
Abstract excerpt
Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are enriched in cellular junctions and essential for tissue development and homeostasis. Mutations of MAGUKs are linked to many human diseases including cancers, psychiatric disorders, and intellectual disabilities. MAGUKs share a common PDZ-SH3-GK tandem domain organization at the C-terminal end. In this review, we summarize...
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