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Article

The Interaction of Caveolin 3 Protein with the Potassium Inward Rectifier Channel Kir2.1

3 May 2013

Abstract excerpt

Mutations in CAV3 cause LQT syndrome 9 (LQT9). A previously reported LQT9 patient had prominent U waves on ECG, a feature that has been correlated with Kir2.1 loss of function. Our objective was to determine whether caveolin 3 (Cav3) associates with Kir2.1 and whether LQT9-associated CAV3 mutations affect the biophysical properties of Kir2.1. Kir2.1 current (I K1 ) density was measured using the whole-cell...

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Share to Cardiac electrophysiology and arrhythmias
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Share to Ion channel regulation and function

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Identifiers

PMID: 23640888
DOI: 10.1074/jbc.m112.435370

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