Article
Assessment of Nurr1 nucleotide variations in familial Parkinson's disease.
Neuroscience letters - 12 Aug 2004
Levecque C, Destée A, Mouroux V, Amouyel P, Chartier-Harlin M-C
Abstract excerpt
Parkinson's disease (PD) is characterised by the death of dopaminergic neurons of the substantia nigra. As Nurr1 seems to regulate the development and maintenance of these neurons, we evaluated its potential role in Parkinson's disease using genetic methods. We genotyped two polymorphisms and screened a case-control sample for the presence/absence of two mutations recently described in exon 1. Our results failed...
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