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Article

Mutations in NR4A2 associated with familial Parkinson disease.

Nature genetics - 1 Jan 2003

Le Wei-Dong, Xu Pingyi, Jankovic Joseph, Jiang Hong, Appel Stanley H, Smith Roy G, Vassilatis Demetrios K

Abstract excerpt

NR4A2, encoding a member of nuclear receptor superfamily, is essential for the differentiation of the nigral dopaminergic neurons. To determine whether NR4A2 is a susceptibility gene for Parkinson disease, we carried out genetic analyses in 201 individuals affected with Parkinson disease and 221 age-matched unaffected controls. We identified two mutations in NR4A2 associated with Parkinson disease (-291Tdel and...

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PMID: 12496759
DOI: 10.1038/ng1066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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