Article
Nurr1 mutational screen in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2004
Tan Eng-King, Chung Henry, Chandran Vandana R, Tan Chris, Shen Hui, Yew Kenneth, Pavanni Ratnagopal, Puvan Kathi-avelu, Wong Meng-Cheong, Teoh Mei-Lin, Yih Yuan, Zhao Yi
Abstract excerpt
We performed sequence analysis of all the exons and exon-intron boundaries in familial and young-onset Parkinson's disease (PD) in an Asian cohort. None of the patients carried any pathogenic mutations in the Nurr1 gene. We demonstrated a 5 to 10% prevalence of the intron 7 +33 C-->T variant among Malay and Indian PD and healthy controls, suggesting that this variant, which was previously described only in 1...
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