Article
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2003
Carmine Andrea, Buervenich Silvia, Galter Dagmar, Jönsson Erik G, Sedvall Göran C, Farde Lars, Gustavsson J Petter, Bergman Hans, Chowdari Kodavali V, Nimgaonkar Vishwajit L, Anvret Maria, Sydow Olof, Olson Lars
Abstract excerpt
We have previously identified mutations in exon three in NURR1 (NR4A2) in two patients with schizophrenia (SZ) and one patient with bipolar disease with psychotic symptoms. In the present study we analyzed the promoter region of NURR1 and identified five polymorphic sites: three were found to be in strong linkage disequilibrium with a previously identified polymorphic site in the sixth intron. One polymorphism of...
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