Article
High frequency of allele-specific down-regulation of HLA class I expression in lung cancer cell lines.
Anticancer research - 1 Jan 2000
Hiraki Akio, Fujii Nobuharu, Murakami Tomoyuki, Kiura Katsuyuki, Aoe Keisuke, Yamane Hiromichi, Masuda Kozo, Maeda Tadashi, Sugi Kazuro, Darzynkiewicz Zbigniew, Tanimoto Mitsune, Harada Mine
Abstract excerpt
Loss or down-regulation of HLA expression has been demonstrated in various types of solid tumors and is considered to be one of the mechanisms of tumor immunoescape. The effectiveness of immunotherapy using tumor-specific antigens (TSA) largely depends on the expression of the appropriate HLA class I alleles on the tumor cells. We analyzed the allele-specific HLA class I surface expression of six lung cancer cell...
Topics
- Alleles
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, Neoplasm
- Down-Regulation
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- HLA Antigens
- Histocompatibility Antigens Class I