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Targeting HLA class I expression to increase tumor immunogenicity

6 Feb 2012

Abstract excerpt

The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor-associated antigens (TAA) by self-HLA (human leukocyte antigen) class I-restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the...

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PMID: 22309256
DOI: 10.1111/j.1399-0039.2011.01831.x

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