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Article

Haplotype Loss of HLA Class I Antigen as an Escape Mechanism from Immune Attack in Lung Cancer

1 Jul 2005

Abstract excerpt

One of tumor escape mechanisms from the host's immunosurveillance system (i.e., a haplotype loss of HLA class I antigens) has been detected in various tumor cells. We hypothesize that the majority of tumor cells with normal HLA class I expression were attacked and eradicated by CTLs, and only a minority with an abnormal expression of HLA class I antigens could escape the host's immunosurveillance system. Using...

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PMID: 15994973
DOI: 10.1158/0008-5472.can-04-3787

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