Article
Debrisoquine hydroxylation phenotyping in geriatric psychopharmacology.
Psychopharmacology bulletin - 1 Jan 1992
Pollock B G, Perel J M, Altieri L P, Kirshner M, Fasiczka A L, Houck P R, Reynolds C F
Abstract excerpt
The metabolic ratios (MRs) between debrisoquine (DBQ) and 4-hydroxydebrisoquine in urine after a single dose of 10 mg DBQ was determined in 175 unmedicated, healthy subjects older than age 59 (mean of 75 years). Creatinine clearance was determined on the same 8-hour urine collection. Test procedures were well tolerated in all cases. Although age was significantly correlated with creatinine clearance (r = -.38),...
Topics
- Aged
- Aged, 80 and over
- Aging
- Debrisoquin
- Female
- Humans
- Hydroxylation
- Male
- Middle Aged
- Phenotype
- Psychopharmacology