Article
3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2006
Zhen Yueying, Slanar Ondrej, Krausz Kristopher W, Chen Chi, Slavík Josef, McPhail Kerry L, Zabriskie T Mark, Perlík Frantisek, Gonzalez Frank J, Idle Jeffrey R
Abstract excerpt
Considerable unexplained intersubject variability in the debrisoquine metabolic ratio (urinary debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. We speculated that debrisoquine was converted to as yet undisclosed metabolites. Thirteen healthy young volunteers, nine CYP2D6*1 homozygotes [extensive metabolizers (EMs)] and four CYP2D6*4 homozygotes [poor metabolizers (PMs)] took 12.8 mg...
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