Article
Venlafaxine serum levels and CYP2D6 genotype.
Therapeutic drug monitoring - 1 Apr 2000
Veefkind A H, Haffmans P M, Hoencamp E
Abstract excerpt
Thirty-three patients with depression treated with 225 mg venlafaxine were genotyped for the polymorphic enzyme, debrisoquine 4-hydroxylase (CYP2D6). The relationship between drug and metabolite levels and between genotype and clinical response were investigated. Although the number of responders in this study is insufficient for definite conclusions to be drawn, a target therapeutic concentration ranging from...
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