Increased expression of mRNA encoding interleukin (IL)‐4 and its splice variant IL‐4δ2 in cells from contacts of <i>Mycobacterium tuberculosis</i>, in the absence of <i>in vitro</i> stimulation

Abstract excerpt

Expression of interleukin (IL)-4 is increased in tuberculosis and thought to be detrimental. We show here that in healthy contacts there is increased expression of its naturally occurring antagonist, IL-4delta2 (IL-4delta2). We identified contacts by showing that their peripheral blood mononuclear cells (PBMC) released interferon (IFN)-gamma in response to the Mycobacterium tuberculosis-specific antigen 6 kDa...

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