Cytokine Gene Expression in Peripheral Blood Mononuclear Cells and Tissues of Cattle Infected with<i>Mycobacterium avium</i>subsp.<i>paratuberculosis</i>: Evidence for an Inherent Proinflammatory Gene Expression Pattern

Abstract excerpt

In cattle and other ruminants, infection with the intracellular pathogen Mycobacterium avium subsp. paratuberculosis results in a granulomatous enteritis (Johne's disease) that is often fatal. The key features of host immunity to M. avium subsp. paratuberculosis infection include an appropriate early proinflammatory and cytotoxic response (Th1-like) that eventually gives way to a predominant antibody-based...

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