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Selective Expression of Type I IFN Genes in Human Dendritic Cells Infected with <i>Mycobacterium tuberculosis</i>

1 Jul 2002

Abstract excerpt

Type I IFN regulates different aspects of the immune response, inducing a cell-mediated immunity. We have recently shown that the infection of dendritic cells (DC) with Mycobacterium tuberculosis (Mtb) induces IFN-alpha. In this work we have monitored a rapid induction of IFN-beta followed by the delayed production of the IFN-alpha1 and/or -alpha13 subtypes. The Mtb infection rapidly activates the NF-kappaB...

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PMID: 12077266
DOI: 10.4049/jimmunol.169.1.366

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