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Article

HIV Skews the Lineage-Defining Transcriptional Profile of <i>Mycobacterium tuberculosis</i>–Specific CD4+ T Cells

1 Mar 2016

Abstract excerpt

HIV-infected persons are at greater risk of developing tuberculosis (TB) even before profound CD4 loss occurs, suggesting that HIV alters CD4(+) T cell functions capable of containing bacterial replication. An effective immune response to Mycobacterium tuberculosis most likely relies on the development of a balanced CD4 response, in which distinct CD4(+) Th subsets act in synergy to control the infection. To...

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PMID: 26927799
DOI: 10.4049/jimmunol.1502094

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