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Article

Construction and function of two Cys146-mutants with high activity, derived from recombinant human soluble B lymphocyte stimulator.

Journal of biochemistry - 1 Jul 2004

Chen Guangyu, Peng Shanyun, Zou Minji, Xu Honglian, Xu Donggang, Wang Jiaxi

Abstract excerpt

B lymphocyte stimulator (BLyS) is a novel member of tumor necrosis factor (TNF) ligand family that is important in B cell maturation and survival. Previous studies were almost related to the function or mechanism of its wild type. Here, we constructed two site-directed mutants of the recombinant human soluble BLyS, the BY-A and BY-V, and found that BY-V ranked the highest whenever in the process of promoting...

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Source

Identifiers

PMID: 15269242
DOI: 10.1093/jb/mvh088

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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