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Article

A single nucleotide mutation drastically increases the expression of tumor-homing NGR-TNFα in the E. coli M15-pQE30 system by improving gene transcription.

Applied microbiology and biotechnology - 1 Feb 2021

Chen Jie, Yang Hao, Feng Yanru, Shi Qiuxiao, Li Zhao, Tao Ze, Fan Jie, Jin Youmei, Li Shengfu, Cheng Jingqiu, Lu Xiaofeng

Abstract excerpt

Due to their potent immune stimulation, tumor necrosis factor alpha (TNFα) variants with tumor-homing activity are attractive as novel antitumor drugs. The promising antitumor effect of NGR-TNFα in clinical trials triggered extensive interest in developing novel tumor-homing TNFα variants in recent years. Owing to its promising antitumor effect, NGR-TNFα is usually used as a control for newly developed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33528691
DOI: 10.1007/s00253-021-11136-x
PMCID: PMC7852052

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