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Article

Alloantibody production is regulated by CD4+ T cells' alloreactive pathway, rather than precursor frequency or Th1/Th2 differentiation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Aug 2004

Sauvé Dominike, Baratin Myriam, Leduc Caroline, Bonin Karina, Daniel Claude

Abstract excerpt

Although CD4(+) T cells play an important role in the regulation of allograft rejection, the exact mechanisms by which they operate and the actual contribution of direct and indirect alloreactivity pathways remain to be fully characterized. Previous studies have established a possible relationship between the indirect alloreactivity pathway and antibody production, but interpretation of these results have been...

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Identifiers

PMID: 15268724
DOI: 10.1111/j.1600-6143.2004.00520.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alloantibody production is regulated by CD4+ T cells' alloreactive pathway, rather than precursor frequency or Th1/Th2 differentiation.PMID 15268724Read ↗

Direct alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivity.Semantic proximity Read ↗

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The importance of the indirect pathway of allorecognition in clinical transplantationSemantic proximity Read ↗

Alloreactive T cells that do not require TCR and CD8 coengagement are present in naive mice and contribute to graft rejection.Semantic proximity Read ↗

Immunodominance Hierarchies and Gender Bias in Direct TCD8-Cell AlloreactivitySemantic proximity Read ↗

High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice.Semantic proximity Read ↗

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T Cells Primed by <i>Leishmania major</i> Infection Cross-React with Alloantigens and Alter the Course of Allograft RejectionSemantic proximity Read ↗

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype.Semantic proximity Read ↗

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