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Article

Direct alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Noël Grégory, Belghith Meriam, Bélanger Benoit, Leduc Caroline, Daniel Claude

Abstract excerpt

The contribution of natural CD4(+)CD25(+) regulatory T cells (nTregs) in controlling graft rejection and the mechanism used remain controversial. Using the duality of the 2.102 TCR Ag recognition, we were able to study, for the first time to our knowledge, the involvement of nTregs in the two pathways of allorecognition in a murine adoptive transfer model in which TCR-transgenic nTregs were or were not depleted...

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PMID: 23440413
DOI: 10.4049/jimmunol.1200190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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