Article
T Cells Primed by <i>Leishmania major</i> Infection Cross-React with Alloantigens and Alter the Course of Allograft Rejection
1 Oct 2002
Abstract excerpt
Alloreactive T lymphocytes can be primed through direct presentation of donor MHC:peptide complexes on graft cells and through indirect presentation of donor-derived determinants expressed by recipient APCs. The large numbers of determinants on an allograft and the high frequency of the alloreactive repertoire has further led to speculation that exposure to environmental Ags may prime T cells that cross-react...
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