Article
Cytokine modulation of TH1/TH2 phenotype differentiation in directly alloresponsive CD4+ human T cells.
Transplantation - 27 Oct 1996
Pawelec G, Rehbein A, Schlotz E, Friccius H, Pohla H
Abstract excerpt
Organ graft rejection is caused by the recognition of allogeneic MHC molecules by recipient T cells by two different pathways. The indirect pathway of alloreactivity requires the presentation of MHC peptides from the graft by autologous APC, as with conventional antigen. The direct pathway, on the other hand, requires the recognition of foreign MHC on foreign cells. The regulatory mechanisms for this component of...
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