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Article

Pathophysiological and genetic characterization of the major diabetes locus in GK rats.

Diabetes - 1 Dec 1999

Galli J, Fakhrai-Rad H, Kamel A, Marcus C, Norgren S, Luthman H

Abstract excerpt

Genetic studies of the type 2 diabetes-like GK rat have revealed several susceptibility loci for the compound diabetes phenotype. Congenic strains were established for Niddm1, the major quantitative trait locus (QTL) for postprandial glucose levels, by transfer of GK alleles onto the genome of the normoglycemic F344 rat. Despite the polygenic nature of diabetes in GK, the locus-specific diabetes phenotype was...

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Identifiers

PMID: 10580437
DOI: 10.2337/diabetes.48.12.2463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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