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Article

Ligand-binding residues integrate affinity and efficacy in the NMDA receptor.

Molecular pharmacology - 1 Aug 2004

Kalbaugh Trisha L, VanDongen Hendrika M A, VanDongen Antonius M J

Abstract excerpt

The interaction of an agonist with its receptor can be characterized by two fundamental properties, affinity and efficacy. Affinity defines how tightly the agonist associates with its receptor, and efficacy measures the ability of the bound ligand to activate the receptor. Although affinity and efficacy are independent properties, the binding and activation processes that they describe are tightly coupled. This...

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Identifiers

PMID: 15266011
DOI: 10.1124/mol.66.2.209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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