Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.

doi:10.1016/j.neuron.2005.05.022

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Article

Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.

Neuron - 7 Jul 2005

Inanobe Atsushi, Furukawa Hiroyasu, Gouaux Eric

Abstract excerpt

Partial agonists produce submaximal activation of ligand-gated ion channels. To address the question of partial agonist action at the NR1 subunit of the NMDA receptor, we performed crystallographic and electrophysiological studies with 1-aminocyclopropane-1-carboxylic acid (ACPC), 1-aminocyclobutane-1-carboxylic acid (ACBC), and 1-aminocyclopentane-1-carboxylic acid (cycloleucine), three compounds with...

Topics

Amino Acids, Cyclic
Animals
Binding, Competitive
Crystallography, X-Ray
Cycloleucine
Electrophysiology
Excitatory Amino Acid Agonists
Female
Kinetics
Ligands
Models, Molecular
Mutation
Oocytes
Patch-Clamp Techniques
Protein Conformation
Rats
Receptors, AMPA
Receptors, Glycine

Source

Open in PubMed

Identifiers

PMID: 15996549
DOI: 10.1016/j.neuron.2005.05.022

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