Article
A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Brain research. Molecular brain research - 10 Nov 1999
Wood M W, VanDongen H M, VanDongen A M
Abstract excerpt
Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.