Article
Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor.
Biochemistry - 21 Dec 2004
Madden Dean R, Cheng Qing, Thiran Shalita, Rajan Shanti, Rigo Frank, Keinänen Kari, Reinelt Stefan, Zimmermann Herbert, Jayaraman Vasanthi
Abstract excerpt
Upon agonist binding, the bilobate ligand-binding domains of the ionotropic glutamate receptors (iGluR) undergo a cleft closure whose magnitude correlates broadly with the efficacy of the agonist. AMPA (alpha-amino-5-methyl-3-hydroxy-4-isoxazolepropionic acid) and kainate are nonphysiological agonists that distinguish between subsets of iGluR. Kainate acts with low efficacy at AMPA receptors. Here we report that...
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