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Article

Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis.

Arthritis and rheumatism - 1 Sept 2004

Myers L K, Tang B, Brand D D, Rosloniec E F, Stuart J M, Kang A H

Abstract excerpt

OBJECTIVE: Previous studies have shown that an analog peptide of the immunodominant T cell determinant of type II collagen (CII), i.e., CII(256-276)(N(263), D(266)), was able to suppress the immune response to CII and the development of arthritis in DR1-transgenic mice. The present study tested the hypothesis that introduction of the same amino acid substitutions into full-length CII might improve the efficacy of...

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Source

Identifiers

PMID: 15457470
DOI: 10.1002/art.20491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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