Article
T-cell receptors and collagen induced arthritis in H-2r mice.
Autoimmunity - 1 Jan 1993
Griffiths M M, Cole B C, Ito J, Harper D S, Anderson G D, Cannon G W, Luthra H S, David C S
Abstract excerpt
Mouse strains B10, B10.RIII, RIIIS/J and the F1 and backcross progeny arising from them were tested for susceptibility to porcine type II collagen-induced arthritis (PII-CIA). The clinically severe arthritis of rapid onset that is characteristic of PII-immunized B10.RIII mice developed predominantly in hybrid offspring that had inherited at least one copy of wild type T cell receptor (TCR) genes (V beta b...
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