Article
Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2015
Haag Sabrina, Tuncel Jonatan, Thordardottir Soley, Mason Daniel E, Yau Anthony C Y, Dobritzsch Doreen, Bäcklund Johan, Peters Eric C, Holmdahl Rikard
Abstract excerpt
Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to a single immunodominant peptide of the immunizing Ag, which does not resemble the autoreactive T cells in RA. An exception is pristane-induced arthritis (PIA) in the rat where...
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