Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen.

doi:10.1084/jem.172.5.1331

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen.

The Journal of experimental medicine - 1 Nov 1990

Watson W C, Thompson J P, Terato K, Cremer M A, Kang A H

Abstract excerpt

Collagen arthritis (CA), an autoimmune model of rheumatoid arthritis (RA), has been studied in various animals. However, it has not been studied in an animal with a genetic background relevant to RA. We selected rats from a diabetic-resistant (DR) subline of the diabetic BB rat because they have...

Topics

Amino Acid Sequence
Animals
Antibody Specificity
Arthritis, Rheumatoid
Collagen
DNA
Diabetes Mellitus, Experimental
Disease Models, Animal
Disease Susceptibility
Epitopes
Genetic Variation
HLA-DR Antigens
Histocompatibility Antigens Class II

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Cellular

Immunity, Innate

Immunoglobulin Variable Region

Incidence

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 1700052
DOI: 10.1084/jem.172.5.1331
PMCID: PMC2188682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1700052-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.