Article
Molecular characterization of an arthritogenic collagen peptide interacting with I-Ar.
Immunology - 1 Jan 2006
Sakurai Yoshihiko, Tang Bo, Rosloniec Edward F, Stuart John M, Kang Andrew H, Myers Linda K
Abstract excerpt
Collagen-induced arthritis (CIA) is an autoimmune arthritis that can be elicited by the immunization of genetically susceptible strains of mice with type II collagen (CII). We have analysed the molecular interactions that occur between an arthritogenic T-cell determinant CII (442-457) and the murine class II susceptibility allele I-A(r). To determine which amino acid residues within the CII (442-457) sequence are...
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