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Article

Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI.

Molecular psychiatry - 1 Dec 2004

den Heijer T, Schuit S C E, Pols H A P, van Meurs J B J, Hofman A, Koudstaal P J, van Duijn C M, Uitterlinden A G, Breteler M M B

Abstract excerpt

The role of estrogens in Alzheimer's disease (AD) is controversial. We investigated the association between well-recognized, and potentially functional, polymorphisms in the estrogen receptor (ER) alpha gene and the risk of AD in a prospective study of 6056 Caucasian older men and women aged 55 years and over. In a subset of 468 participants, we assessed volumes of the hippocampus and amygdala, which have a high...

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Identifiers

PMID: 15263903
DOI: 10.1038/sj.mp.4001553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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