Article
Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.
Annals of neurology - 1 Mar 1998
Jack C R, Petersen R C, Xu Y C, O'Brien P C, Waring S C, Tangalos E G, Smith G E, Ivnik R J, Thibodeau S N, Kokmen E
Abstract excerpt
A variety of anatomic and functional neuroimaging findings are associated with Alzheimer's disease (AD). One of the strongest imaging associations identified is between AD and hippocampal atrophy. The epsilon4 allele of the apolipoprotein E (ApoE) gene increases the risk of developing AD and lowers the mean age of onset of the disease. The purpose of this study was to assess the association between hippocampal...
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