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Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank.

Human brain mapping - 1 Feb 2024

Ambikairajah Ananthan, Khondoker Mizanur, Morris Edward, de Lange Ann-Marie G, Saleh Rasha N M, Minihane Anne Marie, Hornberger Michael

Abstract excerpt

Global prevalence of Alzheimer's Disease has a strong sex bias, with women representing approximately two-thirds of the patients. Yet, the role of sex-specific risk factors during midlife, including hormone replacement therapy (HRT) and their interaction with other major risk factors for Alzheimer's Disease, such as apolipoprotein E (APOE)-e4 genotype and age, on brain health remains unclear. We investigated the...

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Identifiers

PMID: 38339898
DOI: 10.1002/hbm.26612
PMCID: PMC10836173

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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